research
Research inspired by patients, for patients
Cancer Is The Result Of A Disruption Of The Normal Process Of Development & Maturation. We Aim To Understand How Normal Differentiation Goes Awry In The Setting Of Malignancy.
Nucleotide Starvation Is A Metabolic Vulnerability In Malignant Cells. Why? How Can We Therapeutically Target This For The Benefit Of Our Patients?
Transfusions Of Red Blood Cells And Transfusions Of Platelets Are Life-saving for Patients. Why Do We Not Have Neutrophil Transfusions For Patients With Neutropenia Or Neutrophil Dysfunction?
Projects
Understanding why T-ALL is exquisitely sensitive to DHODH inhibition, with a focus on therapeutic combinations.
Elucidating how normal and malignant cells balance their intracellular nucleotide pools.
Determining why prostate cancer has such a tendency to metastasize to the bone marrow, with the goal of identifying vulnerabilities in the tumor immune microenvironment.
Developing differentiation therapy for patients with acute myeloid leukemia, and other malignancies.
Identifying the mechanism that links the inhibition of the metabolic enzyme DHODH and pyrimidine starvation with myeloid differentiation.
Understanding normal neutrophil function with an eye to the development of therapy for patients with neutropenia.
