research
Research inspired by patients, for patients
Cancer Is The Result Of A Disruption Of The Normal Process Of Development & Maturation. We Aim To Understand How Normal Differentiation Goes Awry In The Setting Of Malignancy.
Nucleotide Starvation Is A Metabolic Vulnerability In Malignant Cells. Why? How Can We Therapeutically Target This For The Benefit Of Our Patients?
Transfusions Of Red Blood Cells And Transfusions Of Platelets Are Life-saving for Patients. Why Do We Not Have Neutrophil Transfusions For Patients With Neutropenia Or Neutrophil Dysfunction?
Projects
![nucleotides-project nucleotides-project](https://sykeslab.com/wp-content/uploads/2021/04/nucleotides-project-1.png)
Understanding why T-ALL is exquisitely sensitive to DHODH inhibition, with a focus on therapeutic combinations.
![prostate-project prostate-project](https://sykeslab.com/wp-content/uploads/2021/04/prostate-project-1024x1024.png)
Elucidating how normal and malignant cells balance their intracellular nucleotide pools.
![t-all-project t-all-project](https://sykeslab.com/wp-content/uploads/2021/04/t-all-project-1024x1024.png)
Determining why prostate cancer has such a tendency to metastasize to the bone marrow, with the goal of identifying vulnerabilities in the tumor immune microenvironment.
![dhodh-graphical-abstract-3 dhodh-graphical-abstract-3](https://sykeslab.com/wp-content/uploads/2017/10/dhodh-graphical-abstract-3.jpg)
Developing differentiation therapy for patients with acute myeloid leukemia, and other malignancies.
![shrna-approach shrna-approach](https://sykeslab.com/wp-content/uploads/2017/10/shrna-approach.jpg)
Identifying the mechanism that links the inhibition of the metabolic enzyme DHODH and pyrimidine starvation with myeloid differentiation.
![sykes-lab-research-image-1 sykes-lab-research-image-1](https://sykeslab.com/wp-content/uploads/2017/10/sykes-lab-research-image-1.jpg)
Understanding normal neutrophil function with an eye to the development of therapy for patients with neutropenia.