The Sykes Lab
David grew up on the chilly prairies of Edmonton, Alberta, Canada and completed his undergraduate degree in Biochemistry at the University of Alberta. He transitioned to La Jolla, CA to begin the Medical Scientist Training Program (MSTP) at the University of California San Diego. His PhD research was mentored by Dr. Mark Kamps. Medical internship and residency were done at the Massachusetts General Hospital before fellowship in Hematology & Oncology at the combined Dana Farber Cancer Institute and MGH Cancer Center program. David did an additional year as Chief Resident in the Department of Medicine before starting his post-doctoral research with Dr. David Scadden in the Center for Regenerative Medicine.
David sees patients in clinic on Fridays and spends four 1-week blocks as inpatient attending on the Hematology consult service. He loves to teach hematology to the residents and fellows, as well as spend time at the microscope going over peripheral blood smears.
Outside of the lab, David likes to spend time with his wife, his Golden Retriever (Arlo), and on the golf course.
Chanyce grew up in Revere and graduated from Merrimack college in 2017 with a concentration in molecular cell biology and biotechnology and a minor in business management. She plans to continue her education in hopes of obtaining a Biology/Business Master’s degree. She is always ready for new opportunities. She is not only assisting Dr. Sykes but also Dr. Bardeesy and Dr. Ellisen in the MGH Cancer Center. She is very excited to learn from the three doctors and looks forward to being a part of their research growth. Living in Massachusetts, she has always wanted an opportunity to work in MGH and be a part of their innovative research. In her free time, she enjoys dancing, binge-watching Korean Dramas, and hanging out with her family and friends.
Jelena was born and raised in Stockholm, Sweden where she completed her undergraduate degree in Biomedicine and defended her PhD in 2018 at Karolinska Institutet in the lab of Prof. Per Kogner. During her graduate work, Jelena investigated new treatment strategies in pediatric neural tumors neuroblastoma and medulloblastoma. In September 2018, Jelena joined the Sykes laboratory as a postdoctoral fellow to focus on the mechanism linking the inhibition of DHODH and differentiation in leukemia. In her spare time Jelena enjoys traveling, trying out new foods and experiencing different cultures.
Taghreed earned her PhD in Cancer and Immunology from Claude Bernard University, France in December 2015 under the supervision of Professor Charles Dumontet. Her PhD studies focused on the examination of neutrophils effect on the sensitivity of lymphoma cells to anti-cancer agents. This work had demonstrated how neutrophils attenuate the sensitivity of lymphoma cells to a large variety of anti-cancer agents where similar findings were found in vivo and ex vivo (Hirz et. al, J Vis Exp. 2016; Hirz et. al, Oncotarget 2017).
After completing her PhD, Taghreed moved to The University of Texas MD Anderson Cancer Center for two years of postdoctoral studies on lung cancer, before recognizing her deeply founded interest in tumor microenvironment and immune system, that led her to Boston in April 2018. Taghreed is a shared postdoc between the Baryawno, Sykes and Scadden laboratories, and is currently investigating the biology of prostate cancer and the complexity of the disease bone metastases, which represent glaring unmet medical knowledge to date. Through the utility of scRNA-sequencing, Taghreed seeks to illuminate the complex biology of prostate cancer and the heterogeneity of bone marrow microenvironment; including tumor, stromal, and immune cells; to produce novel insights relevant to tumor-stromal and tumor-immune interactions.
Amy grew up on a small island off the coast of Charleston, South Carolina, and completed her undergraduate work in Microbiology and German at the University of Georgia. She then spent a year abroad doing research before beginning the Medical Scientist Training Program (MSTP) at the Johns Hopkins University School of Medicine. She completed her PhD work on FLT3 signaling in AML under the supervision of Dr. Mark Levis. Shen next pursued pediatric residency training at the Children’s Hospital of Philadelphia (CHOP), before continuing her move up the east coast and landing in Boston for a fellowship in pediatric hematology/oncology at Dana-Farber/Boston Children’s Hospital. After her clinical year of fellowship she has been happy to re-enter the lab, and is excited to be a postdoc with Dr. David Sykes.
In her free time, Amy is a violist with several orchestral and chamber music groups in the Boston area, including the New Philharmonia Orchestra. She also enjoys playing a variety of other instruments, as well as rock climbing and running.
Lab Manager/ Research Technician
Najihah graduated from Rochester Institute of Technology in May 2017 with a major in Biomedical Sciences and a minor in Spanish. During her time at RIT, she spent a year working in an Immunology laboratory that investigated the susceptibility of malaria in different ethnic groups. Following her bachelor’s degree, Najihah joined the Sykes Laboratory at MGH as a Research Technician. She is planning on attending graduate school to pursue PhD in the future because she is excited about research. Outside work, Najihah enjoys cooking, playing the piano and dancing!
Thomas J. Brouse grew up in the historic town of Lewisburg, PA. Majoring in both Biology and Spanish, he graduated summa cum laude from Bucknell University in May of 2018. That same summer, he interned for the Scadden Lab, where he was provided the incredible opportunity to participate in biomedical research with his mentor, Nicolas Severe, PhD. During his internship, Brouse gradually began to appreciate the positive learning environment that is cultivated at MGH, one where he believes he will be able to prosper as a young scientist. In addition, he is animated by all of the innovative research that occurs at MGH’s Center for Regenerative Medicine, and more specifically, in the Sykes Lab. In fact, it is the potential for Dr. Sykes’ research to have a profound impact on the lives of countless patients suffering from debilitating hematological malignancies and other blood-related diseases that attracted Brouse to his lab. Brouse ultimately hopes that he will be able to positively contribute to their efforts of scientific discovery for the benefit of future generations.
Aathmika Lakshmi Krishnan
Research Technician/ Co- Lab Manager
Aathmika was born and raised on the beautiful, sunny coast of San Diego, California. She received her undergraduate degree from Scripps College in LA with a major in Molecular Biology and minor in Mathematics. During college, Aathmika spent her summers working in various labs- one of which was in the Scadden Lab, where she met Dr. Sykes. She enjoys the challenge and curiosity that research begs and is excited to continue her work in The Sykes Lab. Aathmika is inspired by Dr. Sykes’s commitment to the patient and appreciates the smart, hardworking, and lively group of scientists in the Sykes Lab.
During her free time, Aathmika enjoys running, exploring the city, strolling along the Charles River, and travelling.
Research Technician/ Co- Lab Manager
Elizabeth graduated from the University of Wisconsin-Madison in May of 2019 with a Bachelor’s in Genetics and Genomics, and a minor in Public Health. During her undergraduate years, she worked in a microbiology lab that studied sulfur metabolism in freshwater Bacteroidetes. She also spent much of her time volunteering as an EMT. Elizabeth began working in the Sykes Laboratory in the fall of 2019 to support the team’s innovating projects. She is planning to attend graduate school, to pursue a PhD.