research

Research inspired by patients, for patients

Most, if not all, cancer is the result of a disruption of the normal process of development & maturation.

We aim to understand how normal differentiation goes awry in the setting of malignancy.

Using this understanding of normal differentiation as a window into new therapeutic targets, our goal is to make the first step along the road of drug discovery.

Projects

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Developing differentiation therapy for patients with acute myeloid leukemia, and other malignancies.

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Identifying the mechanism that links the inhibition of the metabolic enzyme DHODH and pyrimidine starvation with myeloid differentiation.

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Understanding normal neutrophil function with an eye to the development of therapy for patients with neutropenia.

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