The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia.

David B. Sykes

Expert Opinion on Therapeutic Targets. 2018 Oct 13.

PubMed [journal] PMID:30318938

The Successful Use of Apixaban in Dialysis Patients with Calciphylaxis Who Require RAnticoagulation: A etrospective Analysis.

Garza-Mayers AC, Shah R, Sykes DB, Nigwekar SU, Kroshinsky D.

American Journal of Nephrology. 2018;48(3):168-171.

PubMed [journal] PMID:30176675

Biguanides enhance antifungal activity against Candida glabrata.

Xu S, Feliu M, Lord AK, Lukason DP, Negoro PE, Khan NS, Dagher Z, Feldman MB, Reedy JL, Steiger SN, Tam JM, Soukas AA, Sykes DB, Mansour MK

Virulence. 2018;9(1):1150-1162

PubMed [journal] PMID:29962263 PMCID:PMC6086317

Modulating Cell Fate as a Therapeutic Strategy.

Lin B, Srikanth P, Castle AC, Nigwekar S, Malhotra R, Galloway JL, Sykes DB, Rajagopal J.

Cell Stem Cell. 2018 Sep 6;23(3):329-341

PubMed [journal] PMID: 29910150 PMCID:PMC6128730

Complete Responses in the TEMPI Syndrome after Treatment with Daratumumab.

Sykes DB, Schroyens W

The New England Journal of Medicine. 2018 Jun 7;378(23):2240-2242

PubMed [journal] PMID:29874534

Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages.

Dagher Z, Xu S, Negoro PE, Khan NS, Feldman MB, Reedy JL, Tam JM, Sykes DB, Mansour MK

Frontiers in Immunology. 2018 May 16;9:1058

PubMed [journal] PMID: 29868018 PMCID:PMC5964189

An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections.

Fites JS, Gui M, Kernien JF, Negoro P, Dagher Z, Sykes DB, Nett JE, Mansour MK, Klein BS

PLOS Pathogens. 2018 May 21;14(5):e1007073

PubMed [journal] PMID:29782541 PMCID:PMC5983859


Acquired haemophilia A with a recalcitrant high-titre factor VIII inhibitor in the setting of interstitial lung disease.

Sun L, Sykes DB

BMJ Case Report. 2017 Jul 28;2017. pii: bcr-2017-220932.

PubMed [journal] PMID:28756381

Case 40-2017. A 32-Year-Old Woman with Headache, Abdominal Pain, Anemia, and Thrombocytopenia.

Sykes DB, Rosovsky RP, Singhal AB, Gonzalez RG, Moy AP.

The New England Journal of Medicine. 2017 Dec 28;377(26):2581-2590

PubMed [journal] PMID:29281575

Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.

Kalaitzidis D, Lee D, Efeyan A, Kfoury Y, Nayyar N, Sykes DB, Mercier FE, Papazian A, Baryawno N, Victora GD, Neuberg D, Sabatini DM, Scadden DT.
The Journal of clinical investigation. 2017; 127(4):1405-1413.

PubMed [journal] PMID: 28319048 PMCID: PMC5373863

Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.

Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O’Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J.

Nature medicine. 2017; 23(1):100-106. NIHMSID: NIHMS855786

PubMed [journal] PMID: 27941791 PMCID: PMC5405698


Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.

Lewis TA, Sykes DB, Law JM, Muñoz B, Rustiguel JK, Nonato MC, Scadden DT, Schreiber SL.

ACS medicinal chemistry letters. 2016; 7(12):1112-1117.

PubMed [journal] PMID: 27994748 PMCID: PMC5150668

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT.

Cell. 2016; 167(1):171-186.e15.

PubMed [journal] PMID: 27641501

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.

Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT.

Nature biotechnology. 2016; 34(7):738-45. NIHMSID: NIHMS821329

PubMed [journal] PMID: 27272386 PMCID: PMC5179034

Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse.

Mercier FE, Sykes DB, Scadden DT.

Stem cell reports. 2016; 6(6):985-92.

PubMed [journal] PMID: 27185283 PMCID: PMC4911492

Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy.

Lee D, Wang YH, Kalaitzidis D, Ramachandran J, Eda H, Sykes DB, Raje N, Scadden DT.

The Journal of clinical investigation. 2016; 126(4):1300-10.

PubMed [journal] PMID: 26927669 PMCID: PMC4811118


RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability.

Chen E, Ahn JS, Sykes DB, Breyfogle LJ, Godfrey AL, Nangalia J, Ko A, DeAngelo DJ, Green AR, Mullally A.

Cell reports. 2015; 13(11):2345-52. NIHMSID: NIHMS739343

PubMed [journal] PMID: 26686625 PMCID: PMC4691544

Long-term complete clinical and hematological responses of the TEMPI syndrome after autologous stem cell transplantation.

Kenderian SS, Rosado FG, Sykes DB, Hoyer JD, Lacy MQ.

Leukemia. 2015; 29(12):2414-6.

PubMed [journal] PMID: 26500143

Difficulties in hematopoietic progenitor cell collection from a patient with TEMPI syndrome and severe iatrogenic iron deficiency.

Belizaire R, Sykes DB, Chen YB, Spitzer TR, Makar RS.

Transfusion. 2015; 55(9):2142-8.

PubMed [journal] PMID: 25911963

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.

Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW.

Science (New York, N.Y.). 2015; 349(6247):1261669. NIHMSID: NIHMS794793

PubMed [journal] PMID: 26228159 PMCID: PMC5215039

Hormones and the bone marrow: panhypopituitarism and pancytopenia in a man with a pituitary adenoma.

Lang D, Mead JS, Sykes DB.

Journal of general internal medicine. 2015; 30(5):692-6.

PubMed [journal] PMID: 25583570 PMCID: PMC4395613

Neuregulin1-β decreases IL-1β-induced neutrophil adhesion to human brain microvascular endothelial cells.

Wu L, Walas S, Leung W, Sykes DB, Wu J, Lo EH, Lok J.

Translational stroke research. 2015; 6(2):116-24. NIHMSID: NIHMS599324

PubMed [journal] PMID: 24863743 PMCID: PMC4247352

There Is No Denying It, Our Medical Language Needs an Update.

Sykes DB, Nichols DN.

Journal of graduate medical education. 2015; 7(1):137-8.

PubMed [journal] PMID: 26217448 PMCID: PMC4507913

Hyperhemolysis syndrome in a patient without a hemoglobinopathy, unresponsive to treatment with eculizumab.

Gupta S, Fenves A, Nance ST, Sykes DB, Dzik WS.

Transfusion. 2015; 55(3):623-8.

PubMed [journal] PMID: 25257194

Bone marrow findings of the newly described TEMPI syndrome: when erythrocytosis and plasma cell dyscrasia coexist.

Rosado FG, Oliveira JL, Sohani AR, Schroyens W, Sykes DB, Kenderian SS, Lacy MQ, Kyle RA, Hoyer JD.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2015; 28(3):367-72.

PubMed [journal] PMID: 25216227

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dančík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MA, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL.

Cell reports. 2015; NIHMSID: NIHMS655802

PubMed [journal] PMID: 25660025 PMCID: PMC4524791


Case report: a 37-year-old male with telangiectasias, polycythemia vera, perinephric fluid collections, and intrapulmonary shunting.

Khan J, Sykes DB.

BMC hematology. 2014; 14(1):11.

PubMed [journal] PMID: 25143825 PMCID: PMC4138393


Dectin-1 activation controls maturation of β-1,3-glucan-containing phagosomes.

Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM.
The Journal of biological chemistry. 2013; 288(22):16043-54.
PubMed [journal] PMID: 23609446 PMCID: PMC3668760

Putative RNA-splicing gene LUC7L2 on 7q34 represents a candidate gene in pathogenesis of myeloid malignancies.

Singh H, Lane AA, Correll M, Przychodzen B, Sykes DB, Stone RM, Ballen KK, Amrein PC, Maciejewski J, Attar EC.

Blood cancer journal. 2013; 3:e117.
PubMed [journal] PMID: 23708642 PMCID: PMC3674458

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

Simic P, Zainabadi K, Bell E, Sykes DB, Saez B, Lotinun S, Baron R, Scadden D, Schipani E, Guarente L.
EMBO molecular medicine. 2013; 5(3):430-40.
PubMed [journal] PMID: 23364955 PMCID: PMC3598082


Complete and partial responses of the TEMPI syndrome to bortezomib.

Schroyens W, O’Connell C, Sykes DB.

The New England journal of medicine. 2012; 367(8):778-80.

PubMed [journal] PMID: 22913703

The hematopoietic stem cell niche.

Park D, Sykes DB, Scadden DT.

Frontiers in bioscience (Landmark edition). 2012; 17:30-9. NIHMSID: NIHMS577418

PubMed [journal] PMID: 22201730 PMCID: PMC4020275


The TEMPI syndrome–a novel multisystem disease.

Sykes DB, Schroyens W, O’Connell C.

The New England journal of medicine. 2011; 365(5):475-7.

PubMed [journal] PMID: 21812700


Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia

Sykes DB, Haynes MK, Waller A, Garcia M, Ursu O, Gouveia KE, Sklar L, Lewis TA, Dandapani S, Munoz B, Scadden DT, Palmer M, Schreiber SL.
Bethesda (MD): National Center for Biotechnology Information (US); 2010. Chapter ml390
PubMed [book] PMID: 25834907


The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1.

Scheele JS, Kolanczyk M, Gantert M, Zemojtel T, Dorn A, Sykes DB, Möbest DC, Kamps MP, Räpple D.
Leukemia & lymphoma. 2009; 50(5):816-28.
PubMed [journal] PMID: 19399691


Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages.

Odegaard JI, Vats D, Zhang L, Ricardo-Gonzalez R, Smith KL, Sykes DB, Kamps MP, Chawla A
Journal of leukocyte biology. 2007; 81(3):711-9. NIHMSID: NIHMS17132
PubMed [journal] PMID: 17158607 PMCID: PMC1904487


Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8.

Wang GG, Calvo KR, Pasillas MP, Sykes DB, Häcker H, Kamps MP.
Nature methods. 2006; 3(4):287-93.
PubMed [journal] PMID: 16554834


E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice.

Sykes DB, Kamps MP.
Molecular and cellular biology. 2004; 24(3):1256-69.
PubMed [journal] PMID: 14729970 PMCID: PMC321418


TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism.

Welch JS, Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR, Glass CK.
The Journal of biological chemistry. 2002; 277(45):42821-9.
PubMed [journal] PMID: 12215441

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.

Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK.
Cell. 2002; 109(2):169-80.
PubMed [journal] PMID: 12007404


Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia.

Calvo KR, Knoepfler PS, Sykes DB, Pasillas MP, Kamps MP.
Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(23):13120-5.
PubMed [journal] PMID: 11687616 PMCID: PMC60834

HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.

Knoepfler PS, Sykes DB, Pasillas M, Kamps MP.

Oncogene. 2001; 20(39):5440-8.

PubMed [journal] PMID: 11571641

The HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interaction.

Slupsky CM, Sykes DB, Gay GL, Sykes BD.

Protein science : a publication of the Protein Society. 2001; 10(6):1244-53.

PubMed [journal] PMID: 11369863 PMCID: PMC2374006

2000 & Later

Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression.

Calvo KR, Sykes DB, Pasillas M, Kamps MP.

Molecular and cellular biology. 2000; 20(9):3274-85.

PubMed [journal] PMID: 10757811 PMCID: PMC85621

Granulocyte-macrophage colony-stimulating factor and B7-2 combination immunogene therapy in an allogeneic Hu-PBL-SCID/beige mouse-human glioblastoma multiforme model.

Parney IF, Petruk KC, Zhang C, Farr-Jones M, Sykes DB, Chang LJ.

Human gene therapy. 1997; 8(9):1073-85.

PubMed [journal] PMID: 9189765

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